COLLABORATION WITH PhyMedExp LABORATORY
PHYMEDEXP: Team Ion Channels and Calcium Homeostasis in Cardiac Muscle and Vascular Muscles - University of Montpellier - INSERM
OUR WORK IN COLLABORATION
In 2012 the SLB team started to work with Pr. Jean-Yves Le Guennec from PhyMedExp INSERM laboratory. Pr. Leguennec as electrophysiologist was intereted by understanding the role DHA on calcium channels and was challenged by the fact that oxidized DHA possess more activity than DHA itself. Our group thus started to collaborate, using arrhythmic model and found within the PhD of Jérôme Roy that one oxylipins was able to reduce arrhythmic events for more than 80% and that this oxylipins was not acting as a beta blocker (see publication 25).
With this amazing results, a project team was created implicating Dr. Marie Demion (Associate professor), Dr. Alain Lacampagne (CNRS researcher - DR) to further understand the mode of action of this metabolite.
Our work led to the depository of 6 patents and 10 articles.
COLLABORATION WITH DR. MAGALI GARY-BOBO (IBMM)
Dr. Magali Gary-Bobo is a biologist working in our Institute (IBMM). Dr. Gary-Bobo and her team are working on bioimaging , cancer targeting photodynamic therapy , as well two-photon excitation. Our team started to collaborate in 2023 with Dr. Gary-Bobo to evaluate the anti-cancer activity of the oxylipins synthesized.
Work is ongoing ....