RESEARCH PROJECTS
-BIOACTIVE LIPIDS TEAM-
The team - Synthesis of Bioactive Lipids - lead by Dr. Thierry Durand is part of the Institute of Biomolecules Max Mousseron (IBMM).
The research area of the team focused mainly on polyunsaturated fatty acids (PUFAs) and their metabolites.
Three main research areas are of interest in the group:
- total synthesis of enzymatic and non-enzymatic metabolites of PUFAs
- quantitation of those PUFA metabolites in biological samples
- synthesis of lipid derivatives (lipophenol-PUFA, FAHFA, lipopetides,
My research projects focused on the total synthesis of non-enzymatic and enzymatic metabolites of polyunsaturated fatty acids and their quantitation. More recently, I focused my attention to the synthesis of new metabolite structures from marine biomass (algae, phytoplankton ...).
Total synthesis of non-enzymatic metabolites of PUFA
Quantitation of PUFA metabolites
The quantitation of our compounds is realized in our laboratory by microLC-MS/MS. Our main interest is to develop new extractive technics in different biological fluids and plants, as well as new separative methods, to have robust quantitative measurement of our metabolites and use them as primary standards and biomarkers in various pathologies.
