In 2008, we have developped  an efficient access to isoprostanoids type D, E and F, leading to the synthesis of more than 40 compounds.

For more details on the total synthesis, see the publications.

Thanks to our synthetic strategy, several isoprostanoids are now available in our laboratory.

People interested by these compounds as biomarkers of oxidative stress or to test their biological properties can contact us for collaboration.

We are still working on the synthesis of isoprostanoids:

- towards the A and J types

- the all-cis stereochemistry 

In 2020, we developped  an efficient access to prostaglandin like compounds. The purpose of our work was to prove that prostaglandins (trans-configurated lateral chains) are formed non-enzymatically. We focused our efforts on DHA and EPA derivatives.