- SYNTHESIS OF BIOACTIVE LIPIDS (SLB) - THE TEAM
The team - Synthesis of Bioactive Lipids - lead by Dr. Thierry Durand is part of the Institute of Biomolecules Max Mousseron (IBMM).
The research area of the team focused mainly on polyunsaturated fatty acids (PUFAs) and their metabolites.
Three main research areas are of interest in the group:
- total synthesis of enzymatic and non-enzymatic metabolites of PUFAs
- quantitation of those PUFA metabolites in biological samples
- synthesis of lipid derivatives (lipophenol-PUFA, FAHFA, lipopetides,
- DR OGER PROJECTS -
Dr. Oger research projects focused on the total synthesis of non-enzymatic and enzymatic metabolites of polyunsaturated fatty acids and their quantitation in various matrices. In addition, Dr. Oger focused her effort on finding collaborations to test and find new biological properties of such metabolites.
More especially, since 2016, Dr. Oger focused her attention to the synthesis of new metabolite structures from marine environment (algae, phytoplankton, corals, ...).
For more information on the project team of Dr. Oger, check on Dr. Oger project team.
For more information on the research project of Dr. Oger, go to the end of this page!
DR OGER PROJECTS IN MORE DETAILS
The research work of Dr. Oger and project team focused on:
- the total synthesis of new non-enzymatic metabolites and since 2016 a focus of PUFA metabolites found in marine environment.
- the total synthesis of internal standards for lipidomics
- the total synthesis of new enzymatic metabolites and the research of new biological activities and detection in other matrices.
Total synthesis of Non-Enzymatic metabolites of PUFA
Biomarker Activities of Non-Enzymatic Metabolites
The quantitation of our compounds is performed in our laboratory by microLC-MS/MS. Our main interest is to develop new extractive technics in different biological fluids and plants, as well as new separative methods, to have robust quantitative measurement of our metabolites and use them as primary standards and biomarkers in various pathologies.
Our group is also working in collaboration with analytic laboratories specialized in the quantification of lipids and/or lipid metabolites.
For more details click on the button below or check our articles.
Biological Activities of Non-Enzymatic Metabolites
Thanks to the synthesis of these non-enzymatic metabolites, their biological activities have been tested. Our group thus highlighted the anti-arrhythmic properties of some PUFA non-enzymatic metabolites, the cytotoxicity against cancer cells, the capacity to protect neuronal cells, or anti-inflammatory activities.
Work is still in progress in this field thanks to collaborations we are constantly developing.
For couple details click on the button below or check our articles.
Total synthesis of Enzymatic metabolites of PUFA
Detection of Enzymatic Metabolites in new matrices
The synthesis of enzymatic metabolites that have been extracted from a specific alga species or fungus is a useful tool. Indeed, pure metabolites could be used as standard to study and detect the presence of these metabolites in other matrices or species.
We thus focused our efforts to study other species or matrices where we supposed that these enzymatic metabolites could be found. In this sense, we used the metabolites synthesized as standard in HLPC-MS/MS.
Work is in progress in this area as the first synthesis of marine enzymatic metabolites in our team is new!
Biological Activities of Enzymatic Metabolites
Thanks to the synthesis of these enzymatic metabolites, their biological activities can be tested. Mainly, the enzymatic PUFA metabolites coming from marine environment might possess antimicrobial activities, cytotoxic activities against cancer cells and maybe many more to discover.
Work is in progress in this field as the first syntheses are new!